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钾通道特性中的毒素。

Toxins in the characterization of potassium channels.

作者信息

Castle N A, Haylett D G, Jenkinson D H

出版信息

Trends Neurosci. 1989 Feb;12(2):59-65. doi: 10.1016/0166-2236(89)90137-9.

DOI:10.1016/0166-2236(89)90137-9
PMID:2469212
Abstract

Several recently characterized toxins (apamin, charybdotoxin, dendrotoxin and noxiustoxin) are proving invaluable for establishing what kinds of potassium channel are expressed in neurones, and what the roles of the channels might be.

摘要

最近鉴定出的几种毒素（蜂毒明肽、大蝎毒素、树眼镜蛇毒素和伤害性毒素）对于确定神经元中表达何种钾通道以及这些通道可能发挥什么作用非常有价值。

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1
Toxins in the characterization of potassium channels.钾通道特性中的毒素。
Trends Neurosci. 1989 Feb;12(2):59-65. doi: 10.1016/0166-2236(89)90137-9.
2
Neuromuscular effects of some potassium channel blocking toxins from the venom of the scorpion Leiurus quinquestriatus hebreus.来自以色列金蝎毒液中某些钾通道阻断毒素的神经肌肉效应。
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Dendrotoxin and charybdotoxin increase the cytosolic concentration of free Ca2+ in cerebrocortical synaptosomes: an effect not shared by apamin.树眼镜蛇毒素和蝎毒素可增加大脑皮质突触体中游离Ca2+的胞质浓度：这一效应是蜂毒明肽所没有的。
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Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2.蜂毒明肽敏感的Ca2+激活K+通道rSK2外孔区域的特性分析
Toxicon. 2004 Jun 15;43(8):951-60. doi: 10.1016/j.toxicon.2004.03.025.
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Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K+ channels.蝎毒素阻断对树突毒素敏感的电压激活钾通道。
FEBS Lett. 1989 Jul 3;250(2):519-22. doi: 10.1016/0014-5793(89)80788-4.
7
Comparison of the distribution of binding sites for the potassium channel ligands [125I]apamin, [125I]charybdotoxin and [125I]iodoglyburide in the rat brain.大鼠脑中钾通道配体[125I]蜂毒明肽、[125I]蝎毒素和[125I]碘格列本脲结合位点分布的比较。
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An emerging pharmacology of peptide toxins targeted against potassium channels.针对钾通道的肽毒素的新兴药理学。
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FEBS Lett. 1996 Jul 15;390(1):81-4. doi: 10.1016/0014-5793(96)00616-3.

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