Tartakovskiĭ I S, Marakusha B I, Kuznetsov V V, Nebozhina L V, Prozorovskiĭ S V
Zh Mikrobiol Epidemiol Immunobiol. 1988 Dec(12):104-6.
The action of different preparations of interferon on Legionella strains has been studied in vivo and in vitro. The preparations of leukinferon at a concentration of 500 international units (I.U.) and reaferon at a concentration of 10,000 I.U. have been found to produce an inhibiting effect on Legionella strains in vitro, in a medium with carbon-yeast agar. Leukinferon at a concentration of 125 I.U. suppresses the growth of L. pneumophila also in a liquid medium. The preparation of leukinferon at a minimal concentration of 100 I.U. has been found to suppress the development of lethal infection in chick embryos infected with L. pneumophila strain Philadelphia 1.
已经在体内和体外研究了不同干扰素制剂对军团菌菌株的作用。发现在含有碳酵母琼脂的培养基中，浓度为500国际单位（I.U.）的白细胞干扰素制剂和浓度为10,000 I.U.的重组干扰素制剂在体外对军团菌菌株产生抑制作用。浓度为125 I.U.的白细胞干扰素在液体培养基中也能抑制嗜肺军团菌的生长。已发现最低浓度为100 I.U.的白细胞干扰素制剂能抑制感染嗜肺军团菌费城1型菌株的鸡胚中致死性感染的发展。
