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Cell therapy for avascular osteonecrosis of femoral head.

作者信息

Aoyama T, Toguchida J

机构信息

Institute for Frontier Medical Sciences, Kyoto University , Kyoto, 606-8507, Japan.

出版信息

J Stem Cells Regen Med. 2009 Apr 8;5(1):3-6. doi: 10.46582/jsrm.0501002. eCollection 2009.

DOI:10.46582/jsrm.0501002
PMID:24693035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3908151/
Abstract

Avascular osteonecrosis of femoral head causes severe musculoskeletal disability. There is not standard treatment to cure avascular osteonecrosis. Recently, cell therapy using bone marrow stromal cells has begun for this disease.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/3908151/075fbffb80d1/jsrm-05-004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/3908151/075fbffb80d1/jsrm-05-004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/3908151/075fbffb80d1/jsrm-05-004-g001.jpg

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本文引用的文献

1
Treatment of early stage osteonecrosis of the femoral head.早期股骨头坏死的治疗
J Bone Joint Surg Am. 2008 Nov;90 Suppl 4:175-87. doi: 10.2106/JBJS.H.00671.
2
Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head.移植至股骨头坏死处的间充质干细胞的转归
J Orthop Res. 2009 Apr;27(4):442-6. doi: 10.1002/jor.20759.
3
Steroid-induced osteonecrosis: the number of lesions is related to the dosage.类固醇诱导的骨坏死：病变数量与剂量有关。
J Bone Joint Surg Br. 2008 Sep;90(9):1239-43. doi: 10.1302/0301-620X.90B9.20056.
4
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis.人多能间充质基质细胞分泌血管生成蛋白及其在治疗缺血性骨坏死中的临床潜力。
Leukemia. 2008 Nov;22(11):2054-61. doi: 10.1038/leu.2008.217. Epub 2008 Aug 21.
5
Transplantation of bone marrow mononuclear cells enables simultaneous treatment with osteotomy for osteonecrosis of the bilateral femoral head.骨髓单个核细胞移植可与截骨术同时用于双侧股骨头坏死的治疗。
Med Sci Monit. 2008 Apr;14(4):CS23-30.
6
Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development.早期类固醇相关骨坏死发展过程中骨髓间充质干细胞的脂肪生成增加。
J Orthop Surg Res. 2007 Oct 15;2:15. doi: 10.1186/1749-799X-2-15.
7
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.简要综述：间充质干细胞：其表型、分化能力、免疫特性及归巢潜力
Stem Cells. 2007 Nov;25(11):2739-49. doi: 10.1634/stemcells.2007-0197. Epub 2007 Jul 26.
8
Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion.p16INK4A基因的表达与人骨髓间充质干细胞的衰老密切相关，并且在体外扩增过程中可能因DNA甲基化而沉默。
Stem Cells. 2007 Sep;25(9):2371-82. doi: 10.1634/stemcells.2007-0225. Epub 2007 Jun 14.
9
Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula.组织工程方法治疗类固醇诱导的股骨头坏死：与β-磷酸三钙陶瓷共培养的自体间充质干细胞移植及游离带血管腓骨移植
Artif Organs. 2006 Dec;30(12):960-2. doi: 10.1111/j.1525-1594.2006.00333.x.
10
Regeneration of osteonecrosis of canine scapho-lunate using bone marrow stromal cells: possible therapeutic approach for Kienböck disease.使用骨髓基质细胞再生犬舟月骨坏死：月骨无菌性坏死的可能治疗方法
Cell Transplant. 2006;15(5):411-22. doi: 10.3727/000000006783981800.