Nakajima Yoshiyuki, Masaoka Naoki
Department of Obstetrics and Gynecology, Tokyo Women's Medical University Yachiyo Medical Center, 477-96 Owadashinden, Chiba, Yachiyo, 276-8524, Japan.
Obstet Gynecol Int. 2014;2014:278379. doi: 10.1155/2014/278379. Epub 2014 Feb 13.
Creatine kinase (CK), lactate dehydrogenase (LDH), and amylase levels of preterm infants following long-term tocolysis in pregnant women are limited. The objective of this study was to determine if the tocolytic therapy affects CK, LDH, and amylase levels in the umbilical blood. This study included 215 preterm infants born to women treated with and without ritodrine hydrochloride. CK, LDH, and amylase levels in the umbilical blood at delivery were determined. Infants were divided according to the ritodrine tocolysis, as follows: Group A (n = 91), not exposed to ritodrine; Group B (n = 44), IV ritodrine for <1 week; Group C (n = 80), IV ritodrine for ≥1 week. The CK concentration in cord blood of Group C (198.8 ± 14.2 IU/L) was significantly higher in comparison with Group A (155.0 ± 7.3 IU/L, P < 0.05). There was no significant difference in LDH and amylase levels in the three groups. The CK significantly correlated with gestational age (r = 0.42, P < 0.01) and birth weight (r = 0.38, P < 0.01). LDH and amylase levels did not change with gestational age nor birth weight. In conclusion, long-term ritodrine tocolysis leads to increased umbilical blood CK level.
孕妇长期使用宫缩抑制剂后早产婴儿的肌酸激酶（CK）、乳酸脱氢酶（LDH）和淀粉酶水平有限。本研究的目的是确定宫缩抑制剂治疗是否会影响脐血中的CK、LDH和淀粉酶水平。本研究纳入了215名接受或未接受盐酸利托君治疗的女性所分娩的早产婴儿。测定分娩时脐血中的CK、LDH和淀粉酶水平。婴儿根据利托君宫缩抑制剂治疗情况进行分组，如下：A组（n = 91），未接触利托君；B组（n = 44），静脉注射利托君<1周；C组（n = 80），静脉注射利托君≥1周。与A组（155.0±7.3 IU/L，P < 0.05）相比，C组脐血中的CK浓度（198.8±14.2 IU/L）显著更高。三组的LDH和淀粉酶水平无显著差异。CK与胎龄（r = 0.42，P < 0.01）和出生体重（r = 0.38，P < 0.01）显著相关。LDH和淀粉酶水平不随胎龄和出生体重而变化。总之，长期使用利托君进行宫缩抑制会导致脐血CK水平升高。
