Masoomi Mohammad, Tajoddini Marzieh, Mohammadi Gholamabbas, Malekpoor Reza, Abasi Ebrahim
Cardiology Department, Kerman University of Medical Sciences, Kerman, IR Iran.
Iran Red Crescent Med J. 2013 Oct;15(10):e7842. doi: 10.5812/ircmj.7842. Epub 2013 Oct 5.
Serious health problems and socioeconomic consequences of the illicit use of opiates have been proved in both developed and developing societies.
We aimed to evaluate" The effects of opiate addiction through different administration routes on pulmonary inflammation and its severity."
Our experiments were performed on eighteen adult male Syrian golden hamsters which were allocated to one of the three groups (n = 6): control group which did not receive opiate; the first study group were administered oral opiate via stomach tube; and another study group were administered inhaled opiate. After four weeks, all hamsters were anesthetized with diethyl ether and their lung tissues were isolated for pathological assessment.
Severe perivascular inflammation was detected in 33.3% of the samples with oral opiate dependence and 20% of the cases addicted to opiate through inhalation. Also, severe peribronchial inflammation was observed in only 20% of the samples addicted to inhaled opiate and was not found in the other groups. No significant differences were found in the severity of perivascular and peribronchial inflammation across the three groups. Although the mean of total inflammation scale in the subjects with oral opiate dependence (3.00 ± 1.79) was numerically higher than that in the inhaled dependence group (1.40 ± 2.60) and the controls (2.25 ± 1.26), this difference was not statistically significant.
Administration did not influence the appearance or severity of pulmonary inflammation in animal models addicted to opiate.
在发达社会和发展中社会，非法使用阿片类药物都已被证明会导致严重的健康问题和社会经济后果。
我们旨在评估“通过不同给药途径成瘾的阿片类药物对肺部炎症及其严重程度的影响”。
我们在18只成年雄性叙利亚金仓鼠身上进行了实验，将它们分为三组之一（n = 6）：未接受阿片类药物的对照组；第一个研究组通过胃管给予口服阿片类药物；另一个研究组给予吸入阿片类药物。四周后，所有仓鼠用乙醚麻醉，分离其肺组织进行病理评估。
在33.3%的口服阿片类药物依赖样本和20%的吸入阿片类药物成瘾病例中检测到严重的血管周围炎症。此外，仅在20%的吸入阿片类药物成瘾样本中观察到严重的支气管周围炎症，其他组未发现。三组之间血管周围和支气管周围炎症的严重程度没有显著差异。虽然口服阿片类药物依赖受试者的总炎症评分平均值（3.00±1.79）在数值上高于吸入依赖组（1.40±2.60）和对照组（2.25±1.26），但这种差异没有统计学意义。
给药方式对阿片类药物成瘾动物模型中肺部炎症的出现或严重程度没有影响。
