[干细胞微环境中机械刺激对干细胞分化的研究现状]
[Research status of mechanical stimulation of stem cells differentiation in stem cells microenvironment].
作者信息
Cui Shuangshuang, Zhao Wenjun, Yu Shunlu, Xing Guosheng, Zhao Fengyi
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2014 Jan;28(1):100-4.
OBJECTIVE
To review the relative researches about mechanical stimulation of stem cells differentiation in stem cells microenvironment in vitro.
METHODS
The recent related literature about stem cells differentiation in vitro was reviewed and summarized.
RESULTS
The mechanical loads (including shear stress, mechanical strain, and stress), substrates stiffness, substrates nanotopography, and cell shape were the 4 important aspects of mechanical factors regulating stem cells differentiation. The mechanical stimulation can simulate the in vivo microenvironment, which can alter the size, shape, alignment, and differentiation state of stem cells, can change the expression of their differentiation markers, and can affect the lineage commitment of stem cells.
CONCLUSION
Mechanical stimulation play an important role in regulating stem cells differentiation and cells morphology in addition to chemical and biological factors.
目的
综述体外干细胞微环境中干细胞分化的机械刺激相关研究。
方法
对近期有关干细胞体外分化的相关文献进行回顾与总结。
结果
机械负荷（包括剪切应力、机械应变和应力）、基质硬度、基质纳米拓扑结构和细胞形状是调节干细胞分化的机械因素的4个重要方面。机械刺激可模拟体内微环境，能改变干细胞的大小、形状、排列和分化状态，可改变其分化标志物的表达，并能影响干细胞的谱系定向。
结论
除化学和生物学因素外，机械刺激在调节干细胞分化和细胞形态方面发挥着重要作用。
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