Reck R, Bernal-Sprekelsen M
Universitäts-Hals-Nasen-Ohrenklinik Mainz.
Laryngorhinootologie. 1989 Mar;68(3):152-6. doi: 10.1055/s-2007-998307.
Tricalcium phosphate (TCP) with and without heterologous fibrin glue has been used for obliteration of the mastoid cavity in middle ear surgery. The use of TCP with a homologous fibrin glue has not been described so far. Obliteration of 22 epitympanic and 51 femoral defects in rabbits by means of TCP-granulates without and with homologous fibrin glue was performed in 18 animals. Follow-up was for 2 weeks to 6 months. Histological osteo-integration was studied microscopically. Fibrin glue induces the development of soft tissue impeding osseous integration of the calcium phosphate for at least 6 weeks.
含或不含异源纤维蛋白胶的磷酸三钙（TCP）已被用于中耳手术中乳突腔的填充。目前尚未有关于使用同源纤维蛋白胶的TCP的报道。在18只兔子身上，使用不含和含同源纤维蛋白胶的TCP颗粒对22个上鼓室缺损和51个股骨缺损进行了填充。随访时间为2周至6个月。通过显微镜研究组织学骨整合情况。纤维蛋白胶会诱导软组织生长，至少在6周内阻碍磷酸钙的骨整合。
