化疗药物对人肝癌细胞系体外甲胎蛋白分泌及生长的影响。
Effects of chemotherapeutic agents on alpha-fetoprotein secretion and growth of human hepatoma cell lines in vitro.
作者信息
Muraoka A, Tokiwa T, Sato J
机构信息
Division of Pathology, Okayama University Medical School, Japan.
出版信息
Br J Cancer. 1989 Apr;59(4):569-72. doi: 10.1038/bjc.1989.115.
Abstract
The effects of various chemotherapeutic agents on alpha-fetoprotein (AFP) secretion and growth of human hepatocellular carcinoma and hepatoblastoma cell lines were investigated in vitro. It was found that there was a high correlation between hepatoma cell number and AFP secretion after treatment and that the amount of AFP secreted per cell per 72 h was not affected with therapeutically achievable concentrations. These results suggest that serum AFP level in patients with hepatomas does not correlate with the size of whole tumour but with that of viable tumour mass, and that AFP-secreting capacity of tumour cells in the mass is kept unchanged after chemotherapy.
摘要
在体外研究了各种化疗药物对人肝癌和肝母细胞瘤细胞系甲胎蛋白（AFP）分泌及生长的影响。结果发现，治疗后肝癌细胞数量与AFP分泌之间存在高度相关性，且每72小时每个细胞分泌的AFP量不受治疗可达到的浓度影响。这些结果表明，肝癌患者的血清AFP水平与整个肿瘤大小无关，而与存活肿瘤块大小有关，且化疗后肿瘤块中肿瘤细胞的AFP分泌能力保持不变。
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本文引用的文献
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