α-二氟甲基鸟氨酸对人肝癌细胞系PLC/PRF/5中甲胎蛋白和白蛋白分泌的影响。
Effects of alpha-difluoromethyl ornithine on alpha-fetoprotein and albumin secretion in human hepatoma cell line, PLC/PRF/5.
作者信息
Nakagawa T, Nakao Y, Matsui T, Koizumi T, Watanabe S, Fujita T
出版信息
Cancer Lett. 1985 Sep 30;28(3):245-51. doi: 10.1016/0304-3835(85)90032-1.
PMID:2413987
Abstract
The in vitro effects of alpha-difluoromethyl ornithine (DFMO) on the growth and the secretion of alpha-fetoprotein (AFP) and albumin in human hepatoma cell line PLC/PRF/5 were studied. DFMO caused a marked reduction in the growth rate and de novo synthesis of DNA, whereas secretion of AFP and albumin was not altered. These data indicate that AFP and albumin secretion are neither linked to polyamine synthesis nor to cellular proliferation in human hepatoma cells.
摘要
研究了α-二氟甲基鸟氨酸（DFMO）对人肝癌细胞系PLC/PRF/5生长以及甲胎蛋白（AFP）和白蛋白分泌的体外作用。DFMO导致生长速率显著降低以及DNA的从头合成减少，而AFP和白蛋白的分泌未发生改变。这些数据表明，在人肝癌细胞中，AFP和白蛋白的分泌既不与多胺合成相关，也不与细胞增殖相关。
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