Ibrahim Houssein, Gibard Clémentine, Hesling Cédric, Guillot Régis, Morel Laurent, Gautier Arnaud, Cisnetti Federico
Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand, France.
Dalton Trans. 2014 May 21;43(19):6981-9. doi: 10.1039/c4dt00429a. Epub 2014 Apr 3.
Azide-tagged Cu(I)-NHC reacts in an 'auto-click' process to furnish complexes functionalized by 1,2,3-triazoles bearing diverse substituents. The resulting Cu(I) complexes are amenable to further transmetallation to Au(I). The whole strategy proceeds with mild conditions and constitutes an efficient entry to functionalised metal-NHCs with biorelevant moieties.
叠氮标记的Cu(I)-N-杂环卡宾在“自动点击”过程中发生反应，生成由带有不同取代基的1,2,3-三唑官能化的配合物。所得的Cu(I)配合物易于进一步转金属化为Au(I)。整个策略在温和的条件下进行，是一种高效合成带有生物相关基团的官能化金属-N-杂环卡宾的方法。
