Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, 210008, China.
J Mol Neurosci. 2014 Jun;53(2):242-50. doi: 10.1007/s12031-014-0293-8. Epub 2014 Apr 4.
MicroRNAs (miRNAs) are small (18 ~ 25 nt) noncoding single-stranded RNA molecules that act as negative regulators of gene expression and modulating the stability and/or the translational efficiency of target messenger RNAs. Studies have shown that miRNAs control diverse aspects of brain disease. Recently, several studies have suggested that miRNAs alter the response to ischemia reperfusion injury and regulate the expression of various key elements in cell survival and apoptosis. This review article gives a brief overview of some miRNAs (miR-15a/b, miR-21, miR-29b/c, miR-124, miR-145, miR-181, miR-200 family, miR-338, miR-422a, miR-497, and miR let 7 family) in cerebral ischemia reperfusion injury. Although miRNAs could be potential therapeutic targets for the treatment of ischemia reperfusion injury, their safety and other limitations need further confirmation.
微小 RNA（miRNAs）是一类小的（18~25nt）非编码单链 RNA 分子，作为基因表达的负调控因子，调节靶信使 RNA 的稳定性和/或翻译效率。研究表明，miRNAs 控制着大脑疾病的各个方面。最近，一些研究表明，miRNAs 改变了对缺血再灌注损伤的反应，并调节细胞存活和凋亡中各种关键元素的表达。本文综述了一些在脑缺血再灌注损伤中发挥作用的 miRNAs（miR-15a/b、miR-21、miR-29b/c、miR-124、miR-145、miR-181、miR-200 家族、miR-338、miR-422a、miR-497 和 miR let 7 家族）。尽管 miRNAs 可能成为治疗缺血再灌注损伤的潜在治疗靶点，但它们的安全性和其他限制仍需进一步证实。
