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一例导致睾酮缺乏综合征的分泌促卵泡生成素的垂体大腺瘤

A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome.

作者信息

Wang Xiong, Ge Li, Cui Yuanqing, Lang Cuihong, Hao Cuifang

机构信息

Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China.

Weifang Maternal and Child Health Hospital, Shandong, China.

出版信息

Int J Fertil Steril. 2014 Apr;8(1):99-104. Epub 2014 Mar 9.

PMID:24696774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3973166/
Abstract

FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.

摘要

分泌促卵泡生成素（FSH）的垂体腺瘤可影响性功能和生殖功能。在本文中，我们报告了一例32岁继发性不孕男性的病例。该患者存在性和生殖功能障碍。血液样本检测结果显示睾酮（T）和雌二醇（E2）水平明显降低。基于既往激素检测结果，该患者接受了垂体刺激试验和人绒毛膜促性腺激素（hCG）试验。在垂体刺激试验中，促卵泡生成素（FSH）和促黄体生成素（LH）均显示低反应。hCG试验结果表明T/E2可恢复至正常水平。此外，该患者经垂体磁共振成像（MRI）检查确诊为垂体大腺瘤。该男子术后性和生殖功能恢复。病理结果通过免疫组化染色证实肿瘤组织为分泌FSH的垂体腺瘤。本报告的目的是回顾相关文献，并探讨分泌FSH的垂体腺瘤通过下丘脑-垂体-睾丸轴对激素的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/eefe2f0ea6f1/Int-J-Fertil-Steril-8-99-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/52367dd1444a/Int-J-Fertil-Steril-8-99-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/fa594951d50a/Int-J-Fertil-Steril-8-99-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/c7c2fae38a56/Int-J-Fertil-Steril-8-99-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/eefe2f0ea6f1/Int-J-Fertil-Steril-8-99-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/52367dd1444a/Int-J-Fertil-Steril-8-99-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/fa594951d50a/Int-J-Fertil-Steril-8-99-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/c7c2fae38a56/Int-J-Fertil-Steril-8-99-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cab/3973166/eefe2f0ea6f1/Int-J-Fertil-Steril-8-99-g04.jpg

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本文引用的文献

1
Testicular enlargement in a patient with a FSH-secreting pituitary adenoma.患者患有促卵泡激素分泌型垂体腺瘤，出现睾丸增大。
Endocrine. 2010 Apr;37(2):289-93. doi: 10.1007/s12020-009-9302-z. Epub 2010 Jan 20.
2
A giant FSH-producing pituitary adenoma protruding into the lateral ventricles.一个巨大的分泌促卵泡激素的垂体腺瘤突入侧脑室。
Intern Med. 2008;47(19):1753-4. doi: 10.2169/internalmedicine.47.1405. Epub 2008 Oct 1.
3
Pathology of the human pituitary adenomas.人类垂体腺瘤的病理学
Histochem Cell Biol. 2008 Sep;130(3):495-507. doi: 10.1007/s00418-008-0472-1. Epub 2008 Aug 8.
4
Update in pituitary disease.垂体疾病的最新进展。
J Clin Endocrinol Metab. 2008 Feb;93(2):331-8. doi: 10.1210/jc.2007-1409.
5
Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men.睾酮对男性促黄体生成素分泌的抑制作用，其垂体效应需要芳香化作用，而下丘脑效应则不需要：来自正常男性和促性腺激素释放激素缺乏男性的串联研究证据。
J Clin Endocrinol Metab. 2008 Mar;93(3):784-91. doi: 10.1210/jc.2007-2156. Epub 2007 Dec 11.
6
Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry.垂体肿瘤的病理组织学分类：德国垂体肿瘤登记处10年经验
Eur J Endocrinol. 2007 Feb;156(2):203-16. doi: 10.1530/eje.1.02326.
7
Clinically non-functioning pituitary adenoma.临床无功能垂体腺瘤
Pituitary. 2006;9(4):317-21. doi: 10.1007/s11102-006-0412-9.
8
Hormonal regulation of Leydig cell proliferation and differentiation in rodent testis: a dynamic interplay between gonadotrophins and testicular factors.
Reprod Biomed Online. 2005 Oct;11(4):507-18. doi: 10.1016/s1472-6483(10)61147-9.
9
Gonadotropinomas.促性腺激素瘤
Semin Reprod Med. 2002 Nov;20(4):339-48. doi: 10.1055/s-2002-36708.
10
Best practice policies for male infertility.男性不育的最佳实践政策。
Fertil Steril. 2002 May;77(5):873-82. doi: 10.1016/s0015-0282(02)03105-9.