Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, 2400, Copenhagen NV, Denmark.
Contact Dermatitis. 2014 Aug;71(2):75-81. doi: 10.1111/cod.12229. Epub 2014 Apr 4.
Both atopic dermatitis and contact sensitization are common conditions; however, a definite understanding of the relationship between contact sensitization and atopic dermatitis has not been reached.
In this descriptive study, we investigated the differences between positive patch test reactions in patients with and without atopic dermatitis in a patch test cohort, and explored the influence of disease severity.
PATIENTS/MATERIALS/METHODS: Patch test results, information on atopic dermatitis and demographic variables were taken from a database, including all patients patch tested at Bispebjerg and Roskilde Hospitals from January 2009 to January 2013. Severe atopic dermatitis was defined as systemic therapy or hospitalization resulting from atopic dermatitis. All other patients with atopic dermatitis were defined as having mild/moderate disease.
The study included 2221 patients: 293 patients with atopic dermatitis and 1928 without. Forty-one per cent of patients with and 46.2% of patients without atopic dermatitis had at least one positive patch test reaction (p = 0.092). More patients with severe atopic dermatitis than patients with non-severe atopic dermatitis had multiple positive patch test reactions (19.4% versus 10.0%, p = 0.046).
Overall, we found similar frequencies of positive patch test reactions in patients with and without atopic dermatitis. However, a higher frequency of multiple sensitizations was found in patients with severe atopic dermatitis.
特应性皮炎和接触致敏都是常见的疾病；然而，对于接触致敏与特应性皮炎之间的关系，尚未有明确的认识。
在本描述性研究中，我们在一个斑贴试验队列中研究了特应性皮炎患者和无特应性皮炎患者的阳性斑贴试验反应之间的差异，并探讨了疾病严重程度的影响。
患者/材料/方法：从一个数据库中获取了 2009 年 1 月至 2013 年 1 月在比斯加夫和罗斯基勒医院接受斑贴试验的所有患者的斑贴试验结果、特应性皮炎信息和人口统计学变量。严重特应性皮炎定义为特应性皮炎导致的全身治疗或住院。所有其他特应性皮炎患者均定义为轻度/中度疾病。
该研究纳入了 2221 例患者：293 例特应性皮炎患者和 1928 例无特应性皮炎患者。有特应性皮炎的患者中 41%和无特应性皮炎的患者中 46.2%至少有一个阳性斑贴试验反应（p=0.092）。与非重度特应性皮炎患者相比，重度特应性皮炎患者有多个阳性斑贴试验反应的患者更多（19.4%对 10.0%，p=0.046）。
总体而言，我们发现有特应性皮炎和无特应性皮炎的患者的阳性斑贴试验反应频率相似。然而，在重度特应性皮炎患者中，发现了更高频率的多重致敏。
