Lomnitzer R
Medical Research Council Human Cellular Immunology Unit, School of Pathology, South African Institute for Medical Research, Johannesburg.
J Clin Lab Immunol. 1988 Oct;27(2):91-6.
Isoprinosine, a synthetic purine derivative, enhanced the proliferative response of peripheral blood mononuclear cells to the lectin phytohaemagglutinin, and to the monoclonal antibody OKT3. The drug did not potentiate the activation of cells following oxidation by sodium periodate. Isoprinosine had no effect on the expression of receptors for interleukin-2. Increased interleukin-2 activity was detected in three out of nine supernatants from PHA activated mononuclear cells which were cultured in the presence of isoprinosine. Kinetic experiments involving addition or removal of the drug at various time intervals indicated that potentiation of the proliferative response required the presence of the drug at both early and late stages of cell activation. Inhibition of mononuclear cell activation by cyclosporine A was not affected by isoprinosine. These results suggest that enhancement of mononuclear cell proliferation by isoprinosine involves events in both early and late stages of the activation cycle.
异丙肌苷，一种合成嘌呤衍生物，增强了外周血单核细胞对凝集素植物血凝素和单克隆抗体OKT3的增殖反应。该药物在高碘酸钠氧化后不会增强细胞的活化。异丙肌苷对白细胞介素-2受体的表达没有影响。在存在异丙肌苷培养的PHA活化单核细胞的九个上清液中，有三个检测到白细胞介素-2活性增加。涉及在不同时间间隔添加或去除药物的动力学实验表明，增殖反应的增强需要在细胞活化的早期和晚期都存在该药物。环孢素A对单核细胞活化的抑制不受异丙肌苷的影响。这些结果表明，异丙肌苷增强单核细胞增殖涉及活化周期早期和晚期的事件。
