Johns A, Freay A D, Adams D J, Lategan T W, Ryan U S, van Breemen C
Department of Pharmacology and Medicine, University of Miami School of Medicine, Florida.
J Cardiovasc Pharmacol. 1988;12 Suppl 5:S119-23.
The involvement of calcium in the release of EDRF from cultured endothelial cells is reviewed. It is suggested that both intracellular and extracellular calcium can release EDRF depending not only on the experimental conditions but also on the agonist involved in the release. Calcium enters the cell, following receptor occupation, through a nonselective receptor-operated channel. Intracellular release of calcium following receptor occupation is probably via the production of inositol trisphosphate (IP3). It is suggested that the initial calcium signal for the release of endothelium-derived relaxant factor (EDRF) is of intracellular origin whereas the maintained release of EDRF is due to calcium entry from the extracellular space.
本文综述了钙在培养的内皮细胞释放内皮舒张因子（EDRF）过程中的作用。研究表明，细胞内钙和细胞外钙均可释放EDRF，这不仅取决于实验条件，还取决于参与释放过程的激动剂。受体被占据后，钙通过非选择性受体操纵通道进入细胞。受体被占据后细胞内钙的释放可能是通过三磷酸肌醇（IP3）的产生。研究表明，内皮源性舒张因子（EDRF）释放的初始钙信号来源于细胞内，而EDRF的持续释放则是由于细胞外钙的内流。
