Mulvany M J, Aalkjaer C
Biophysics Institute, Aarhus University, Denmark.
J Cardiovasc Pharmacol. 1988;12 Suppl 5:S134-8.
This paper reviews in vitro investigations of resistance vessels taken from individuals with essential hypertension and from spontaneously hypertensive rats (SHRs). Unlike mesenteric resistance vessels from SHRs, the calcium sensitivity of subcutaneous resistance vessels from essential hypertensive patients is not increased, but decreased. However, like the resistance vessels from SHRs, the structure of the resistance vessels from the essential hypertensive patients (expressed in terms of their media thicknesses) was increased. In studies with SHRs, the increased media are found to be associated with cellular hyperplasia. If this also is true for the resistance vasculature of patients with essential hypertension, this may explain findings that antihypertensive treatment reduces blood pressure more readily than vascular structure. These findings could also be relevant as regards the rather limited effect of such treatment on hypertension-related diseases such as infarction.
本文综述了对原发性高血压患者和自发性高血压大鼠（SHR）的阻力血管进行的体外研究。与SHR的肠系膜阻力血管不同，原发性高血压患者皮下阻力血管的钙敏感性并未增加，反而降低。然而，与SHR的阻力血管一样，原发性高血压患者的阻力血管结构（以中膜厚度表示）增加。在对SHR的研究中，发现中膜增厚与细胞增生有关。如果原发性高血压患者的阻力血管系统也是如此，这可能解释了抗高血压治疗比血管结构更容易降低血压的现象。这些发现对于此类治疗对梗死等高血压相关疾病的相当有限的效果也可能具有相关性。
