Lucot J B, Crampton G H, Matson W R, Gamache P H
Department of Pharmacology, Wright State University, Dayton, OH 45435.
Life Sci. 1989;44(18):1239-45. doi: 10.1016/0024-3205(89)90359-7.
Six female cats, varying in susceptibility to motion sickness, were implanted with chronic cannulae in the rostral portion of the fourth ventricle. The cats were then challenged with a motion sickness-inducing stimulus. Samples of cerebrospinal fluid were withdrawn before and after emesis or 30 min of motion if emesis did not occur and again on control (no motion) days. The samples were analyzed by HPLC with an array of 16 coulometric detectors. Thirty-six compounds were identified in the samples. Baseline levels of DOPAC, MHPGSO4, uric acid, DA, 5-HIAA and HVA were lower on motion and control days in cats which became motion sick when compared with cats which did not become motion sick. None of the identified compounds varied as a function of either exposure to motion or provocation of emesis. It is concluded that susceptibility to motion sickness is a manifestation of individual differences related to fundamental neurochemical composition.
六只对晕动病易感性不同的雌性猫，在第四脑室前部植入了慢性套管。然后让这些猫接受诱发晕动病的刺激。在呕吐前后或如果未发生呕吐则在运动30分钟后抽取脑脊液样本，在对照（无运动）日也抽取样本。通过配备16个库仑检测器阵列的高效液相色谱法对样本进行分析。在样本中鉴定出36种化合物。与未患晕动病的猫相比，患晕动病的猫在运动日和对照日的3,4-二羟基苯乙酸（DOPAC）、3-甲氧基-4-羟基苯乙二醇硫酸酯（MHPGSO4）、尿酸、多巴胺（DA）、5-羟色胺（5-HIAA）和高香草酸（HVA）的基线水平较低。所鉴定的化合物均未随运动暴露或呕吐激发而变化。得出的结论是，晕动病易感性是与基本神经化学成分相关的个体差异的一种表现。
