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对一所私人住宅中因接触气压计中的汞而受影响儿童进行的生物监测。

Biological monitoring involving children exposed to mercury from a barometer in a private residence.

作者信息

Scheepers Paul T J, van Ballegooij-Gevers Marieke, Jans Henk

机构信息

Office for Health, Environment & Safety, Public Health Services Brabant/Zeeland, Tilburg, The Netherlands; Department for Health Evidence, Radboudumc, Nijmegen, The Netherlands.

Office for Health, Environment & Safety, Public Health Services Brabant/Zeeland, Tilburg, The Netherlands.

出版信息

Toxicol Lett. 2014 Dec 15;231(3):365-73. doi: 10.1016/j.toxlet.2014.03.017. Epub 2014 Mar 31.

Abstract

A small spill of approximately 3 mL of mercury from a broken barometer in a residential setting resulted in blood values of 32 μg/L in a boy of 9 months and 26 μg/L in a girl of 2.5 years in samples collected within 6h after the start of the incident. A nanny who attempted to remove the spill had a blood mercury value of 20 μg/L at the same time point. These elevated blood values were attributed to inhalation rather than dermal uptake or ingestion. Exposure was aggravated by the use of a vacuum cleaner in an early attempt to remove the spill and incomplete decontamination of involved persons, leading to a continuation of exposure. Over a period of three months general cleaning was followed by targeted cleaning of hot spots until the indoor air mercury levels reached a median value of 0.090 μg/m(3) with a range of 0.032-0.140 μg/m(3). Meanwhile the family was staying in a shelter home. Human biological monitoring (HBM) was motivated by the complex exposure situation and the involvement of young children. Initially high blood values triggered alertness for clinical signs of intoxication, that (as it turned out) were not observed in any of the exposed individuals. Despite continued exposure from hair and clothes, within six weeks after the incident, blood levels returned to a background level normally seen in children. HBM contributed to reassurance of the parents of the young children that quick elimination of the mercury did not require medical treatment.

摘要

在一个居民住宅环境中,一个气压计破裂导致约3毫升汞泄漏。在事件发生后6小时内采集的样本中,一名9个月大的男孩血液汞值为32微克/升,一名2.5岁女孩血液汞值为26微克/升。一名试图清理泄漏汞的保姆在同一时间点血液汞值为20微克/升。这些血液汞值升高归因于吸入,而非皮肤吸收或摄入。早期试图用吸尘器清理泄漏汞以及对相关人员去污不彻底,加剧了暴露,导致暴露持续。在三个月的时间里,先进行了全面清洁,随后对热点区域进行了针对性清洁,直到室内空气中汞水平达到中位数0.090微克/立方米,范围为0.032 - 0.140微克/立方米。与此同时,这家人住在临时安置所。复杂的暴露情况以及幼儿的卷入促使进行人体生物监测(HBM)。最初较高的血液汞值引发了对中毒临床症状的警惕,但结果是在任何暴露个体中均未观察到这些症状。尽管头发和衣服持续造成暴露,但在事件发生后六周内,血液汞水平恢复到儿童通常的背景水平。人体生物监测有助于让幼儿的父母放心,汞的快速清除无需医疗治疗。

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