二氧化碳激光汽化联合光动力疗法治疗尖锐湿疣。
The combination of CO2 laser vaporation and photodynamic therapy in treatment of condylomata acuminata.
机构信息
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Xiangya Hospital, Central South University, Changsha 410008, PR China.
出版信息
Photodiagnosis Photodyn Ther. 2014 Jun;11(2):130-3. doi: 10.1016/j.pdpdt.2014.03.008. Epub 2014 Mar 31.
The aim of this study was to investigate the effectiveness of CO2 laser vaporation and topical PDT combination on condylomata acuminate (CA) located in the perianal and external genital area. A total of 119 patients (perianal CA=52 cases and external genital CA=67 cases) with at least one CA lesion >2mm were treated with monopulse CO2 laser followed by topical ALA-PDT. PDT was repeated till complete response was achieved. Approximately half of the patients only needed one session of PDT treatment and another half needed multiple PDT treatments to achieve complete response. During the 6-month follow-up 7.1% of patients relapsed. In terms of complete response rate and recurrence rate there were no statistical differences between perianal and genital groups. No severe adverse effects were observed. CO2 laser vaporation plus ALA-PDT is a highly effective modality for treating CA.
本研究旨在探讨 CO2 激光汽化联合局部光动力疗法（ALA-PDT）治疗肛周和外生殖器部位尖锐湿疣（CA）的疗效。共纳入 119 例至少存在 1 处＞2mm 尖锐湿疣皮损的患者，采用单脉冲 CO2 激光治疗后，外用 ALA-PDT。当达到完全缓解时停止 PDT 治疗。约一半的患者仅需一次 PDT 治疗，另一半患者则需要多次 PDT 治疗以达到完全缓解。6 个月随访期间，7.1%的患者复发。在完全缓解率和复发率方面，肛周组和生殖器组之间无统计学差异。未观察到严重不良反应。CO2 激光汽化联合 ALA-PDT 是治疗 CA 的一种高效方法。
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