Department of Pathology, Basic Medical Science College, Harbin Medical University, Harbin, China.
Dermatology. 2012;225(4):364-70. doi: 10.1159/000346330. Epub 2013 Feb 13.
Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate.
To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser and CO2 laser alone for CA treatment in mainland China.
In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO2 laser, and CO2 laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared.
The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ(2) = 271.98, p < 0.0001).
ALA-PDT combined with CO2 laser was more effective in decreasing the recurrence rate of CA compared with CO2 laser alone. It might offer a wide clinical application for CA treatment.
尖锐湿疣是由人乳头瘤病毒引起的。大多数尖锐湿疣的传统治疗方法复发率较高。
比较中国大陆地区 5-氨基酮戊酸光动力疗法（ALA-PDT）联合二氧化碳激光与单纯二氧化碳激光治疗尖锐湿疣的复发率。
本荟萃分析共纳入 22 篇文章的 2048 例尖锐湿疣患者，分为两组。治疗组采用 ALA-PDT 联合二氧化碳激光治疗，对照组采用单纯二氧化碳激光治疗。计算并比较两组的复发率。
对照组的复发率为 42.67%（451/1,057），治疗组的复发率为 10.29%（102/991），两组间差异有统计学意义（χ²=271.98，p<0.0001）。
与单纯二氧化碳激光相比，ALA-PDT 联合二氧化碳激光治疗可降低尖锐湿疣的复发率，为尖锐湿疣的治疗提供了更广阔的临床应用前景。
