一名接受多种酪氨酸激酶抑制剂治疗5年的患者发生急性主动脉夹层。
Acute aortic dissection in a patient receiving multiple tyrosine kinase inhibitors for 5 years.
作者信息
Funahashi Y, Sassa N, Inada-Inoue M, Ando Y, Matsukawa Y, Gotoh M
机构信息
Department of Urology, Nagoya University Graduate School of Medicine, Nagoya University Hospital, Nagoya, Japan.
Department Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.
出版信息
Aktuelle Urol. 2014 Mar;45(2):132-4. doi: 10.1055/s-0033-1363274. Epub 2014 Apr 3.
A 48-year-old male presented with para-aortic lymph node metastases after surgical resection of a clear cell renal cell carcinoma. After first-line treatment with interferon alpha-2b, he was started on pazopanib and lapatinib. Blood pressure was well controlled with temocapril and amlodipine. Treatment had to be stopped 4 years and 8 months after initiation due to overt proteinuria. Then, sunitinib was started as third-line treatment. During the second cycle of sunitinib, he died due to a Stanford type A aortic dissection. Acute aortic dissection could be an adverse event associated with the long-term use of antiangiogenic tyrosine kinase inhibitors.
一名48岁男性在接受透明细胞肾细胞癌手术切除后出现主动脉旁淋巴结转移。在接受一线α-2b干扰素治疗后，他开始使用帕唑帕尼和拉帕替尼。通过替莫卡普利和氨氯地平，血压得到了良好控制。由于明显蛋白尿，治疗在开始4年零8个月后不得不停止。然后，舒尼替尼作为三线治疗开始使用。在舒尼替尼的第二个疗程中，他因A型主动脉夹层死亡。急性主动脉夹层可能是长期使用抗血管生成酪氨酸激酶抑制剂相关的不良事件。
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