Fillipas S, Tanamas S K, Davies-Tuck M L, Wluka A E, Wang Y, Holland A E, Cherry C L, Cicuttini F
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia Alfred Hospital, Melbourne, Australia.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Int J STD AIDS. 2015 Feb;26(2):133-8. doi: 10.1177/0956462414531404. Epub 2014 Apr 3.
Obesity is a risk factor for osteoarthritis. Antiretroviral therapy (ART)-treated HIV-infected patients are frequently affected by overweight and obesity, and may be at increased risk of osteoarthritis. BMI however is a measure which does not discriminate adipose from non-adipose body mass, or fat distribution, which may have different effects. This study aimed to examine relationships between body composition and knee cartilage volume, as assessed by magnetic resonance imaging in HIV infection. 35 ART-treated HIV-infected men aged 51.7 years (mean) 7.9 (SD) and 18 healthy men aged 49.5 years (mean) 6.4 (SD) participated. Cartilage volume was measured on magnetic resonance imaging of the dominant knee using validated methods. Body composition was measured using dual x-ray absorptiometry. HIV-infected participants had less total body and gynoid fat (kg) (p = 0.04 and p = 0.007, respectively) and more percent android fat mass and percent trunk fat mass (p = 0.001 and p < 0.001, respectively) than controls. In HIV-infected participants there was an inverse association between total body fat mass and average tibial cartilage volume (R = -8.01, 95% CI -15.66, -0.36). Also, in HIV-infected participants there was an inverse association between android fat mass and average cartilage volume (R = -90.91, 95% CI -158.66, -23.16). This preliminary study found that both total body and android fat mass were inversely related to average knee cartilage volume in ambulant, ART-treated HIV-infected adults. These findings are features of early knee osteoarthritis and this may be of future significance in HIV.
肥胖是骨关节炎的一个风险因素。接受抗逆转录病毒疗法（ART）治疗的HIV感染患者经常受到超重和肥胖的影响，并且可能有更高的骨关节炎风险。然而，体重指数（BMI）是一种无法区分脂肪与非脂肪体重或脂肪分布的测量方法，而脂肪分布可能有不同影响。本研究旨在通过磁共振成像评估HIV感染患者的身体成分与膝关节软骨体积之间的关系。35名接受ART治疗的HIV感染男性（平均年龄51.7岁，标准差7.9岁）和18名健康男性（平均年龄49.5岁，标准差6.4岁）参与了研究。使用经过验证的方法在优势膝关节的磁共振成像上测量软骨体积。使用双能X线吸收法测量身体成分。与对照组相比，HIV感染参与者的全身脂肪和臀部脂肪（千克）更少（分别为p = 0.04和p = 0.007），而男性型脂肪质量百分比和躯干脂肪质量百分比更高（分别为p = 0.001和p < 0.001）。在HIV感染参与者中，全身脂肪质量与平均胫骨软骨体积之间存在负相关（R = -8.01，95%可信区间-15.66，-0.36）。此外，在HIV感染参与者中，男性型脂肪质量与平均软骨体积之间存在负相关（R = -90.91，95%可信区间-158.66，-23.16）。这项初步研究发现，在接受ART治疗的能行走的HIV感染成年人中，全身脂肪和男性型脂肪质量均与平均膝关节软骨体积呈负相关。这些发现是早期膝关节骨关节炎的特征，这在HIV患者中可能具有未来意义。
