Inoue Motoki, Sakane Masataka, Taguchi Tetsushi
Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
J Biomed Mater Res B Appl Biomater. 2014 Nov;102(8):1786-91. doi: 10.1002/jbm.b.33165. Epub 2014 Apr 3.
Leakage of bone cement into the spinal canal has been reported to cause many adverse effects. In this study, we designed an implantable balloon kyphoplasty material that avoids cement leakage through the formation of covalent bonds with the bone cement. For this purpose, glycidyl methacrylate (GMA) was used as a reactive functional group attached to the poly(vinyl alcohol) (PVA) membrane. The prepared membrane adhered to poly(methyl methacrylate) (PMMA)-based bone cements within 10 min, which is the time required for PMMA polymerization in the bone cement. The bonding strength between the GMA-PVA membrane and the PMMA-based bone cement was higher than that for the original PVA membrane, likely because vinyl bonds form between the surface of the GMA-PVA membrane and the bone cement. Since the GMA-PVA membrane adhered firmly to the PMMA-based bone cement, the membrane was able to completely cover the PMMA-based bone cement.
据报道，骨水泥渗漏至椎管会引发诸多不良反应。在本研究中，我们设计了一种可植入式球囊椎体后凸成形术材料，该材料通过与骨水泥形成共价键来避免骨水泥渗漏。为此，甲基丙烯酸缩水甘油酯（GMA）被用作连接到聚乙烯醇（PVA）膜上的反应性功能基团。制备的膜在10分钟内就与聚甲基丙烯酸甲酯（PMMA）基骨水泥粘附，而这正是骨水泥中PMMA聚合所需的时间。GMA - PVA膜与PMMA基骨水泥之间的粘结强度高于原始PVA膜，这可能是因为GMA - PVA膜表面与骨水泥之间形成了乙烯基键。由于GMA - PVA膜牢固地粘附在PMMA基骨水泥上，所以该膜能够完全覆盖PMMA基骨水泥。
