Dumusc A, So A
Rev Med Suisse. 2014 Mar 12;10(421):590, 592-4.
Rheumatoid arthritis (RA), in addition to the traditional joint damage can affect all organs as a systemic disease. Extra-articular manifestations of RA are highly variable ranging from rheumatoid nodules (most common) to rheumatoid vasculitis presenting a significant morbidity and mortality (49% at 5 years). With the new algorithms of treatment (earlier) and the use of biologics, the incidence of severe extra-articular manifestations decreases. Regarding the treatment of rheumatoid vasculitis, rituximab looks promising. RA also increases cardiovascular risk and the risk of osteoporosis. It is therefore important to identify these risks and, if appropriate, treat them. Collaboration with the general practitioner is essential in this situation.
类风湿关节炎（RA）作为一种全身性疾病，除了传统的关节损伤外，还会影响所有器官。RA的关节外表现多种多样，从类风湿结节（最常见）到类风湿血管炎，后者具有较高的发病率和死亡率（5年时为49%）。随着新的（更早的）治疗方案和生物制剂的使用，严重关节外表现的发生率有所下降。关于类风湿血管炎的治疗，利妥昔单抗看起来很有前景。RA还会增加心血管疾病风险和骨质疏松风险。因此，识别这些风险并在适当的时候进行治疗非常重要。在这种情况下，与全科医生合作至关重要。
