Peles Einat, Schreiber Shaul, Adelson Miriam
a Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse, Treatment and Research, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
Subst Abus. 2014;35(3):226-9. doi: 10.1080/08897077.2014.899944.
The objective was to study substance abuse, infectious disease, and patient outcomes (retention and substance abuse abstinence) over 2 decades in a large methadone maintenance treatment (MMT) facility within a tertiary-referral medical center.
Prevalence of substance abuse was determined monthly between 1993 (35 patients) and 2013 (350 patients) based on observed random urine tests. On entry, patients were tested for hepatitis C and human immunodeficiency virus (HIV) antibodies. One-year retention and substance abuse abstinence were calculated.
At admission, mean age and rate of cocaine and benzodiazepines abuse increased over the years, with no change in the prevalence of hepatitis C (50%) and HIV (<10%). Retention rate increased (P = .008) (range: 42.9%-92.4%; overall: 76.2%) and opiate abstinence also increased (P = .006) (range: 49.1%-85.7%; overall: 68.1%), reflecting outcome improvement over the years.
Outcome improvement could be attributed to the staff's growing experience and improvements in treatment but also to changes in patient characteristics over the past 2 decades.
目的是研究在一家三级转诊医疗中心的大型美沙酮维持治疗（MMT）机构中，超过20年期间的药物滥用、传染病及患者结局（留存率和药物滥用戒断情况）。
基于观察到的随机尿液检测结果，在1993年（35名患者）至2013年（350名患者）期间每月确定药物滥用的患病率。入院时，对患者进行丙型肝炎和人类免疫缺陷病毒（HIV）抗体检测。计算一年的留存率和药物滥用戒断率。
入院时，多年来可卡因和苯二氮䓬类药物滥用的平均年龄和发生率有所增加，丙型肝炎患病率（50%）和HIV患病率（<10%）无变化。留存率有所提高（P = .008）（范围：42.9% - 92.4%；总体：76.2%），阿片类药物戒断率也有所提高（P = .006）（范围：49.1% - 85.7%；总体：68.1%），反映出多年来结局有所改善。
结局改善可能归因于工作人员经验的增加和治疗的改进，但也归因于过去20年患者特征的变化。
