State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Chin J Nat Med. 2014 Mar;12(3):225-8. doi: 10.1016/S1875-5364(14)60038-8.
To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae)
The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.
A total of sixteen compounds, including five xanthones (5, 7-10), five saccharide esters (1, 3, 4, 12, 13), two flavonoids (14, 16), two triterpenoids (11, 15), one phenylpropanoid (6), and one benzophenone glycoside (2) were isolated. Their structures were determined as sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3, 4, 5-trimethoxycinnamic acid (6), 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone (7), 1, 3, 7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1, 2, 3, 6, 7-pentamethoxyxanthone (10), presenegenin (11), 3'-O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose (12), tenuifoliside C (13), 5, 3'-dihydroxy-7, 4'-dimethoxyflavonol-3-O-β-D-glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O-β-D-glucopyranoside (16).
Compounds 1 and 2 are two new compounds from P. sibirica.
研究西伯利亚远志（远志科）根的化学成分。
采用溶剂提取和各种色谱技术（包括硅胶、Sephadex LH-20、ODS、半制备 HPLC 和制备 TLC）进行分离。根据 HR-ESI-MS 和 1D-和 2D-NMR 光谱数据等广泛的光谱分析，阐明了化学结构。
共分离得到十六种化合物，包括五种酮（5、7-10）、五种糖酯（1、3、4、12、13）、两种黄酮（14、16）、两种三萜（11、15）、一种苯丙素（6）和一种苯并二氧六环糖苷（2）。它们的结构被确定为西伯利亚醇 A7（1）、西伯利亚苯酮 A（2）、远志糖 A（3）、远志糖 C（4）、兰西酮（5）、3,4,5-三甲氧基肉桂酸（6）、6-羟基-1,2,3,7-四甲氧基酮（7）、1,3,7-三羟基-2-甲氧基酮（8）、奥尼克斯酮 II（9）、1,2,3,6,7-五甲氧基酮（10）、前egenin（11）、3'-O-3,4,5-三甲氧基肉桂酰-6-O-4-甲氧基苯甲酰蔗糖（12）、细叶远志糖苷 C（13）、5,3'-二羟基-7,4'-二甲氧基黄酮醇-3-O-β-D-吡喃葡萄糖苷（14）、细叶远志苷（15）和鼠李素 3-O-β-D-吡喃葡萄糖苷（16）。
化合物 1 和 2 是西伯利亚远志中的两种新化合物。
