Delplanque B, Emmerich J, Norol F, Jourdan D, Duedari N, Jacotot B
INSERM U 32, Hôpital Henri-Mondor, Créteil.
Ann Med Interne (Paris). 1988;139 Suppl 1:80-2.
Three patients with heterozygote type IIa hyperlipoproteinemia were treated by specific LDL apheresis with a dextran sulfate-cellulose column every two weeks. Each apheresis resulted in a fall in total cholesterolemia of about 50 p. 100 with a parallel fall in apoprotein B. The average drop of 15 p. 100 in HDL-cholesterol appeared to be due to the hemodilution induced at the end of apheresis. After two months, cholesterol and apoprotein B concentrations before removal were 15 p. 100 lower than baseline values. Treatment was well tolerated. These findings appear encouraging for the treatment of heterozygote forms of familial hyperlipoproteinemia resistant to chemotherapy.
三名杂合子IIa型高脂蛋白血症患者每两周接受一次使用硫酸葡聚糖 - 纤维素柱的特异性低密度脂蛋白分离术治疗。每次分离术后，总胆固醇血症下降约50%，载脂蛋白B也相应下降。高密度脂蛋白胆固醇平均下降15%似乎是由于分离术结束时引起的血液稀释所致。两个月后，去除前的胆固醇和载脂蛋白B浓度比基线值低15%。治疗耐受性良好。这些发现对于治疗对化疗耐药的家族性高脂蛋白血症杂合子形式似乎很有前景。
