不耍猴戏：灵长类动物中干细胞和祖细胞的克隆追踪。

No monkeying around: clonal tracking of stem cells and progenitors in the macaque.

机构信息

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston MA 02115, USA.

Laboratory of Ageing Biology and Stem Cells, European Research Institute for Biology of Ageing, University Medical Center Groningen, University of Groningen, 9700 AD, Groningen, The Netherlands.

出版信息

Cell Stem Cell. 2014 Apr 3;14(4):419-20. doi: 10.1016/j.stem.2014.03.006.

DOI:10.1016/j.stem.2014.03.006

PMID:24702990

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4083228/

Abstract

Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014) and Wu et al. (2014) extend these analyses to nonhuman primates, providing insights into dynamics of HSPC expansion and lineage commitment following autologous transplantation.

摘要

造血干细胞和祖细胞（HSPCs）的克隆追踪已被证明对于研究其在小鼠受体内的行为非常有价值。现在，Kim 等人（2014 年）和 Wu 等人（2014 年）将这些分析扩展到非人类灵长类动物，为自体移植后 HSPC 扩增和谱系决定的动态提供了新的见解。