在PAM - 212角质形成细胞中，环己酰亚胺、佛波酯和视黄酸诱导产生的白细胞介素 - 1α信使核糖核酸会被地塞米松降低。
Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes.
作者信息
McGuire J, Langdon R, Birchall N, Kupper T
机构信息
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510.
出版信息
Ann N Y Acad Sci. 1988;548:283-90. doi: 10.1111/j.1749-6632.1988.tb18816.x.
Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid. Dexamethasone decreases the amount of IL-1 mRNA induced by these agents, as well as constitutive IL-1 alpha mRNA. RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.
培养中的角质形成细胞组成性地产生可检测量的IL-1α mRNA，并且可以被放线菌酮、佛波酯和视黄酸刺激以表达增加量的IL-1α mRNA。地塞米松减少这些试剂诱导的IL-1 mRNA量以及组成性IL-1α mRNA。RU 486干扰糖皮质激素受体结合，减少地塞米松对佛波酯刺激IL-1α mRNA的抑制，这表明地塞米松的抑制作用是通过传统的配体-受体机制。
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