Multiple Sclerosis Center, Utano National Hospital, 8 Ondoyama-machi, Ukyo-ku, Kyoto, 616-8255, Japan.
Department of Neurology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0265, Japan.
J Neuroimmunol. 2014 May 15;270(1-2):98-9. doi: 10.1016/j.jneuroim.2014.03.001. Epub 2014 Mar 11.
The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.
髓鞘少突胶质细胞糖蛋白（MOG）被认为是中枢神经系统脱髓鞘疾病的候选标志物。在这里，我们使用基于细胞的免疫荧光测定法，用全长人 MOG cDNA 对 48 例连续的日本脊髓炎或视神经炎（ON）患者血清样本（抗水通道蛋白 4（AQP）4 抗体阴性）和 14 例抗 AQP4 Ab 阳性患者进行了抗 MOG Ab 检测。在 4 例男性脊髓炎或 ON 患者中检测到抗 MOG Ab。总体而言，13 例视神经脊髓炎谱系疾病抗体阴性和所有抗 AQP4 Ab 阳性患者均为抗 MOG Ab 阴性。因此，这些发现需要在大型队列系列中进一步检查。
