抗髓鞘少突胶质细胞糖蛋白抗体在中枢神经系统脱髓鞘疾病成年患者中的表现
Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system.
机构信息
Multiple Sclerosis Center, Utano National Hospital, 8 Ondoyama-machi, Ukyo-ku, Kyoto, 616-8255, Japan.
Department of Neurology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0265, Japan.
出版信息
J Neuroimmunol. 2014 May 15;270(1-2):98-9. doi: 10.1016/j.jneuroim.2014.03.001. Epub 2014 Mar 11.
The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.
髓鞘少突胶质细胞糖蛋白（MOG）被认为是中枢神经系统脱髓鞘疾病的候选标志物。在这里，我们使用基于细胞的免疫荧光测定法，用全长人 MOG cDNA 对 48 例连续的日本脊髓炎或视神经炎（ON）患者血清样本（抗水通道蛋白 4（AQP）4 抗体阴性）和 14 例抗 AQP4 Ab 阳性患者进行了抗 MOG Ab 检测。在 4 例男性脊髓炎或 ON 患者中检测到抗 MOG Ab。总体而言，13 例视神经脊髓炎谱系疾病抗体阴性和所有抗 AQP4 Ab 阳性患者均为抗 MOG Ab 阴性。因此，这些发现需要在大型队列系列中进一步检查。
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