髓鞘少突胶质细胞糖蛋白抗体阳性视神经炎中类固醇脉冲疗法反应性的评估
Evaluation of Steroid Pulse Therapy Responsiveness in Myelin-Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis.
作者信息
Takai Yasuyuki, Yamagami Akiko, Iwasa Mayumi, Inoue Kenji, Wakakura Masato, Takahashi Toshiyuki, Tanaka Keiko
机构信息
Department of Ophthalmology, Inouye Eye Hospital, Tokyo, JPN.
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, JPN.
出版信息
Cureus. 2024 Mar 21;16(3):e56673. doi: 10.7759/cureus.56673. eCollection 2024 Mar.
PURPOSE
Myelin-oligodendrocyte glycoprotein antibody-positive optic neuritis (MOGON) is usually responsive to the steroid, but, for some patients, steroid pulse therapy alone may be inadequate. This study aimed to investigate the factors predicting the response to steroid pulse therapy in MOGON.
METHODS
This study included 17 patients (24 eyes) with MOGON, who received single steroid pulse therapy as initial treatment. Best corrected visual acuity (BCVA) and mean deviation (MD) values after treatment were examined concerning findings at onset.
RESULTS
No correlation was found between BCVA at onset and after treatment, but a correlation was observed between MD values at onset and after treatment (correlation coefficient 0.48, p=0.01, Spearman's rank correlation coefficient). Age, gender, duration from onset to treatment, magnetic resonance imaging findings, and optical coherence tomography findings did not affect visual function after treatment.
CONCLUSIONS
Severe visual field impairment at onset may indicate that additional treatment may be necessary.
目的
髓鞘少突胶质细胞糖蛋白抗体阳性视神经炎（MOGON）通常对类固醇有反应，但对于一些患者，仅类固醇脉冲疗法可能并不足够。本研究旨在调查预测MOGON患者对类固醇脉冲疗法反应的因素。
方法
本研究纳入了17例（24只眼）MOGON患者，他们接受单次类固醇脉冲疗法作为初始治疗。根据发病时的检查结果，对治疗后的最佳矫正视力（BCVA）和平均偏差（MD）值进行了检查。
结果
治疗前后的BCVA之间未发现相关性，但治疗前后的MD值之间存在相关性（相关系数0.48，p = 0.01，Spearman等级相关系数）。年龄、性别、发病至治疗的持续时间、磁共振成像结果和光学相干断层扫描结果均不影响治疗后的视觉功能。
结论
发病时严重的视野损害可能表明需要额外的治疗。
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