Grimm Martin, Munz Adelheid, Teriete Peter, Nadtotschi Tatjana, Reinert Siegmar
Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jun;117(6):743-53. doi: 10.1016/j.oooo.2014.02.007. Epub 2014 Feb 22.
Tumor hypoxia is a crucial negative prognostic factor associated with outcome of oral squamous cell carcinoma (OSCC).
Expression of glucose transporter 1 (GLUT-1) (solute carrier family 2 [facilitated glucose transporter], member 1 [SLC2A1]) was analyzed in OSCC specimen (n = 161) and cancer cell lines by immunohistochemistry and Western blotting. GLUT-1 expression on protein level was correlated with transketolase-like 1 (TKTL1) expression, clinical characteristics, and effect on survival. Subgroup analysis was performed for GLUT-1/TKTL1 coexpression.
GLUT-1 expression was significantly correlated with TKTL1 expression (P < .0001) and recurrence of the tumor (P = .001). Multivariate analysis did not find GLUT-1 expression to be an independent prognostic factor (P = .2478). GLUT-1(+)/TKTL1(+) subgroup showed the worst effect on survival compared with the GLUT-1(-)/TKTL1(-) subgroup (P = .0002).
This study provides evidence that tumors linked with combined enhanced glucose uptake (GLUT-1(+)) and hypoxia-related glucose metabolism (TKTL1(+)) characteristics (GLUT-1(+)/TKTL1(+) coexpression) are associated with shorter survival in OSCC.
肿瘤缺氧是与口腔鳞状细胞癌（OSCC）预后相关的关键负面预后因素。
通过免疫组织化学和蛋白质印迹法分析了161例OSCC标本及癌细胞系中葡萄糖转运蛋白1（GLUT-1）（溶质载体家族2[促进性葡萄糖转运蛋白]，成员1[SLC2A1]）的表达。GLUT-1蛋白水平的表达与转酮醇酶样1（TKTL1）的表达、临床特征及对生存的影响相关。对GLUT-1/TKTL1共表达进行亚组分析。
GLUT-1表达与TKTL1表达（P <.0001）及肿瘤复发（P =.001）显著相关。多因素分析未发现GLUT-1表达是独立的预后因素（P =.2478）。与GLUT-1（-）/TKTL1（-）亚组相比，GLUT-1（+）/TKTL1（+）亚组对生存的影响最差（P =.0002）。
本研究提供的证据表明，具有增强的葡萄糖摄取（GLUT-1（+））和缺氧相关葡萄糖代谢（TKTL1（+））联合特征（GLUT-1（+）/TKTL1（+）共表达）的肿瘤与OSCC患者较短的生存期相关。
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