Hospital of Stomatology, Sun Yat-Sen University, Guangzhou 510055, Guangdong, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong, China.
Aging (Albany NY). 2021 Feb 26;13(5):7284-7299. doi: 10.18632/aging.202583.
Glycolysis markers including glucose transporter 1 (GLUT1), monocarboxylate transporter 4 (MCT4), hexokinase 2 (HK2), pyruvate kinase M2 (PKM2) and glucose transporter 4 (GLUT4) play vital roles in head and neck squamous cell carcinoma (HNSCC). However, their prognostic value in HNSCC is still controversial. In this meta-analysis, we searched the PubMed, Web of Science and Cochrane Library databases and included thirty-seven studies (3272 patients) that met the inclusion criteria. Higher expression levels of the glycolysis markers in tumor tissues correlated with poorer overall survival (OS; < 0.001), disease-free survival (DFS; = 0.03) and recurrence-free survival (RFS; < 0.001) of HNSCC patients. Subgroup and sensitivity analyses demonstrated that higher expression levels of GLUT1 ( < 0.001), MCT4 ( = 0.002), HK2 ( = 0.002) and PKM2 ( < 0.001) correlated with poorer OS among HNSCC patients. Higher expression of MCT4 ( < 0.001) and PKM2 ( = 0.008) predicted poorer DFS among HNSCC patients. However, GLUT4 expression levels did not associate with clinical outcomes in HNSCC patients. These results demonstrate that glycolysis markers, such as GLUT1, MCT4, HK2 and PKM2, are potential prognostic predictors and therapeutic targets in HNSCC.
糖酵解标志物，包括葡萄糖转运蛋白 1（GLUT1）、单羧酸转运蛋白 4（MCT4）、己糖激酶 2（HK2）、丙酮酸激酶 M2（PKM2）和葡萄糖转运蛋白 4（GLUT4），在头颈部鳞状细胞癌（HNSCC）中发挥着重要作用。然而，它们在 HNSCC 中的预后价值仍存在争议。在这项荟萃分析中，我们检索了 PubMed、Web of Science 和 Cochrane Library 数据库，并纳入了符合纳入标准的 37 项研究（3272 名患者）。肿瘤组织中糖酵解标志物的高表达与 HNSCC 患者的总生存期（OS；<0.001）、无病生存期（DFS；=0.03）和无复发生存期（RFS；<0.001）较差相关。亚组和敏感性分析表明，GLUT1（<0.001）、MCT4（=0.002）、HK2（=0.002）和 PKM2（<0.001）的高表达与 HNSCC 患者的 OS 较差相关。MCT4（<0.001）和 PKM2（=0.008）的高表达预示着 HNSCC 患者的 DFS 较差。然而，GLUT4 表达水平与 HNSCC 患者的临床结局无关。这些结果表明，糖酵解标志物，如 GLUT1、MCT4、HK2 和 PKM2，是 HNSCC 潜在的预后预测因子和治疗靶点。
