类花生酸在κ-卡拉胶诱导的大鼠尾部血栓形成中的作用。
Role of eicosanoids in the kappa-carrageenin rat tail thrombosis.
作者信息
Bekemeier H, Hirschelmann R
机构信息
Dept. of Pharmacology, Martin Luther University, GDR, Halle.
出版信息
Biomed Biochim Acta. 1988;47(10-11):S260-3.
Pretreatment of rats by the cyclooxygenase inhibitors diclofenac, phenylbutazone, and aminophenazone did not influence kappa-carrageenin (KC) rat tail thrombosis (RTT) whereas pretreatment by aspirin, at high doses, and particularly sulfinpyrazone decreased RTT frequency, PGI2 or iloprost i.v. injection showed strong RTT preventing effects as it was also seen by thromboxane synthesis inhibitors (benzydamine, imidazole) at high doses. The PAF antagonist BN 52020 weakly protected. Lipoxygenase inhibitors (quercetin, oxphaman a.o.) proved ineffective. Therefore, thromboxane/PGI2 balance and partly PAF seem to be involved in the mechanism of KC RTT.
用环氧化酶抑制剂双氯芬酸、保泰松和氨基比林对大鼠进行预处理，不会影响κ-角叉菜胶（KC）诱导的大鼠尾部血栓形成（RTT），而高剂量阿司匹林预处理，尤其是磺吡酮预处理可降低RTT频率，静脉注射前列环素（PGI2）或伊洛前列素显示出很强的预防RTT的作用，高剂量的血栓素合成抑制剂（苄达明、咪唑）也有此作用。血小板活化因子（PAF）拮抗剂BN 52020的保护作用较弱。脂氧合酶抑制剂（槲皮素、奥扎莫尔等）无效。因此，血栓素/PGI2平衡以及部分PAF似乎参与了KC诱导的RTT机制。
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