Bertelli A, Bertelli A A, Giovannini L
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Drugs Exp Clin Res. 1994;20(1):7-11.
The aim of the present experiments was to ascertain whether prostacycline could exercise a protective effect against the formation of thrombosis in the rat tail induced by endothelin and K-carrageenin and to compare the effect of prostacycline with that of carnitine and propionyl carnitine. Both prostacycline and propionyl carnitine exhibited a similar protective effect on this experimental model. A combined protective effect of prostacycline administered with carnitine was also observed and a possible interaction between these two substances is proposed.
本实验的目的是确定前列环素是否能对由内皮素和κ-卡拉胶诱导的大鼠尾部血栓形成发挥保护作用，并比较前列环素与肉碱及丙酰肉碱的作用效果。前列环素和丙酰肉碱对该实验模型均表现出相似的保护作用。还观察到前列环素与肉碱联合应用的保护作用，并提出了这两种物质之间可能存在相互作用。
