非酒精性脂肪性肝病男性适度饮酒与颈动脉斑块或颈动脉狭窄

Modest alcohol consumption and carotid plaques or carotid artery stenosis in men with non-alcoholic fatty liver disease.

作者信息

Sinn Dong Hyun, Gwak Geum-Youn, Cho Juhee, Son Hee Jung, Paik Yong-Han, Choi Moon Seok, Lee Joon Hyeok, Koh Kwang Cheol, Paik Seung Woon, Yoo Byung Chul

机构信息

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea; Department of Internal Medicine, Sanggye Paik Hospital, Inje University School of Medicine, South Korea.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea.

出版信息

Atherosclerosis. 2014 Jun;234(2):270-5. doi: 10.1016/j.atherosclerosis.2014.03.001. Epub 2014 Mar 21.

DOI:10.1016/j.atherosclerosis.2014.03.001

PMID:24704629

Abstract

BACKGROUND

Favorable association between modest alcohol consumption and cardiovascular disease had been reported in general population, however, whether observed benefit extend to men with established fatty liver disease remains unknown.

METHODS

Cross-sectional study of 10,581 consecutive male participants aged 30 years or older undergoing abdominal ultrasonography and carotid artery ultrasonography were screened. Non-alcoholic fatty liver disease (NAFLD) was diagnosed with ultrasonography and exclusion of secondary causes for fat accumulation or other causes of chronic liver disease. Modest alcohol use was defined as consumption of less than 20 g of alcohol per day.

RESULTS

There were total 2280 men diagnosed with fatty liver, and the mean age was 51.8 years old. Among them, 1797 were modest alcohol drinkers. The prevalence of carotid plaques (55.3% vs. 43.4%, p < 0.001) and carotid artery stenosis (11.0% vs. 5.5%, p < 0.001) was higher in non-drinkers than modest drinkers. Modest alcohol consumption had the independent inverse association with carotid plaques [odd ratio (OR): 0.74, 95% confidence interval (CI): 0.60-0.92] and carotid artery stenosis (OR: 0.62, 95% CI: 0.43-0.90), adjusted for age, smoking and metabolic syndrome.

CONCLUSIONS

Modest alcohol consumption had a favorable association with carotid plaque or CAS in men with NAFLD.

摘要

背景

一般人群中曾有报道称适度饮酒与心血管疾病之间存在有益关联，然而，这种观察到的益处是否适用于已确诊患有脂肪肝疾病的男性尚不清楚。

方法

对10581名年龄在30岁及以上连续接受腹部超声检查和颈动脉超声检查的男性参与者进行横断面研究。通过超声检查并排除脂肪堆积的继发性原因或其他慢性肝病病因来诊断非酒精性脂肪性肝病（NAFLD）。适度饮酒定义为每天饮酒量少于20克。

结果

共有2280名男性被诊断患有脂肪肝，平均年龄为51.8岁。其中，1797人是适度饮酒者。不饮酒者的颈动脉斑块患病率（55.3%对43.4%，p<0.001）和颈动脉狭窄患病率（11.0%对5.5%，p<0.001）高于适度饮酒者。在调整年龄、吸烟和代谢综合征后，适度饮酒与颈动脉斑块[比值比（OR）：0.74，95%置信区间（CI）：0.60 - 0.92]和颈动脉狭窄（OR：0.62，95%CI：0.43 - 0.90）呈独立负相关。