Serotonin modulates calcium-dependent plateau of action potentials recorded from bull frog A-type sensory neurons which is omega-conotoxin GVIA-sensitive, but dihydropyridine-insensitive.

Tetraethylammonium-treated bull frog sensory neurons exhibit a calcium-dependent plateau on the falling limb of the action potential, which is reduced in duration by 5-HT. The portion of the calcium-dependent plateau which is reduced by 5-HT is blocked by omega-conotoxin GVIA but is not reduced by nifedipine or enhanced by Bay K 8644. The lack of effect of 5-HT, when retested after exposure of a previously 5-HT sensitive neuron to conotoxin favors the hypothesis that 5-HT reduces the duration of the calcium-dependent plateau by inactivating voltage-dependent calcium channels, rather than by increasing a voltage-dependent potassium current.