Zheng Hui, Xue Song, Hu Zhen-Lei, Shan Jiang-Gui, Yang Wen-Gang
Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
J Cardiovasc Pharmacol. 2014 Sep;64(3):285-92. doi: 10.1097/FJC.0000000000000102.
There is no agreement on whether statins influence the incidence of atrial fibrillation after coronary artery bypass grafting. We performed a meta-analysis of 12 studies that compared statins with controls. Statin therapy significantly reduced the incidence of postoperative atrial fibrillation (POAF) (odds ratio, 0.50; 95% confidence interval, 0.35-0.73) and length of hospital stay (weighted mean difference, -0.72; 95% confidence interval, -0.99 to -0.45), an effect that survived detailed subgroup analysis. Meta-regression analysis revealed that patient characteristics did not influence the extent of improvement in the incidence of POAF attributable to statins. In conclusion, patients undergoing coronary artery bypass grafting benefit from perioperative treatment with statins, which significantly reduce the incidence of POAF and length of hospital stay.
关于他汀类药物是否会影响冠状动脉搭桥术后房颤的发生率，目前尚无定论。我们对12项比较他汀类药物与对照组的研究进行了荟萃分析。他汀类药物治疗显著降低了术后房颤（POAF）的发生率（比值比，0.50；95%置信区间，0.35 - 0.73）以及住院时间（加权平均差，-0.72；95%置信区间，-0.99至-0.45），这一效果在详细的亚组分析中依然存在。荟萃回归分析显示，患者特征并不影响他汀类药物所致POAF发生率的改善程度。总之，接受冠状动脉搭桥术的患者从围手术期使用他汀类药物治疗中获益，这显著降低了POAF的发生率和住院时间。
