Jiang M
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1988 Sep;10(5):357-9.
Established human cancer cell lines derived from liver cancer (BEL-7402), nasopharyngeal cancer (CNE-2) and stomach cancer (MGC-803) were used in this study. These human cancer cells have been serially transplanted in nude mice. As determined by clonogenic assay, pingyangmycin (bleomycin A5) was highly cytotoxic to these three cell lines, of which the liver cancer cell line was more sensitive than the other two. At a tolerated dose level, pingyangmycin exhibited a remarkable growth inhibition on the growth of the liver cancer and stomach cancer xenografts, the inhibition rates being 70% and 85%, respectively. No pathologic changes were found in the organs of treated animals.
本研究使用了源自肝癌（BEL - 7402）、鼻咽癌（CNE - 2）和胃癌（MGC - 803）的已建立的人类癌细胞系。这些人类癌细胞已在裸鼠中连续传代移植。通过克隆形成试验测定，平阳霉素（博来霉素A5）对这三种细胞系具有高度细胞毒性，其中肝癌细胞系比其他两种更敏感。在耐受剂量水平下，平阳霉素对肝癌和胃癌异种移植物的生长表现出显著的生长抑制作用，抑制率分别为70%和85%。在接受治疗的动物器官中未发现病理变化。
