Wiedemann R, Strowitzki T, Sandner R, Luppa P, Hepp H
Frauenklinik im Klinikum Grosshadern der Ludwig-Maximilians-Universität München.
Geburtshilfe Frauenheilkd. 1989 Mar;49(3):237-42. doi: 10.1055/s-2008-1035745.
In 112 clinical pregnancies after IVF/ET or GIFT, the importance of beta-HCG progesterone and 17 beta-estradiol was evaluated. Additionally, we performed a vaginosonography to confirm an early intrauterine pregnancy. The aim of the study was to define, when a clinical pregnancy can be detected as early as possible and when the differential diagnosis of intact or abnormal pregnancy can be made. By measuring E2 in an HCG substituted cycle, the diagnosis of a clinical pregnancy is possible as soon as day +12 after induction of ovulation. When considering beta-HCG levels alone, the same diagnosis can be made at day +18. Single determinations of HCG level do not offer a satisfactory diagnosis, because of intra-individual variations. A progesterone drop always demonstrates a disturbed early pregnancy. Using a combination of hormonal serial measurements of HCG, E2, progesterone and vaginosonography, the diagnosis of an intact intrauterine pregnancy should be possible as early as day +27 after ovulation induction.
在112例体外受精/胚胎移植（IVF/ET）或配子输卵管内移植（GIFT）后的临床妊娠中，评估了β-人绒毛膜促性腺激素（β-HCG）、孕酮和17β-雌二醇的重要性。此外，我们进行了阴道超声检查以确认早期宫内妊娠。本研究的目的是确定何时能够尽早检测到临床妊娠，以及何时能够对正常或异常妊娠进行鉴别诊断。通过在HCG替代周期中测量雌二醇（E2），在排卵诱导后第12天即可诊断临床妊娠。仅考虑β-HCG水平时，在第18天可做出相同诊断。由于个体差异，单次测定HCG水平无法提供令人满意的诊断。孕酮水平下降总是表明早期妊娠受到干扰。结合使用HCG、E2、孕酮的激素系列测量和阴道超声检查，在排卵诱导后第27天应可诊断正常宫内妊娠。
