Mazzucconi M G, Ferrari A, Vignetti M, Giona F, Girolami D, Martinelli E, Mandelli F
Haematologica. 1989 Jan-Feb;74(1):63-6.
We performed 56 HDIVG administrations in adults (26) and children (30) affected by idiopathic thrombocytopenic purpura with two different schedules: a five-day course at 400 mg/kg/d and a "bolus" 1 gr/kg. Forty-five cases were treated in preparation for surgical operations and eleven for bleeding episodes. Response to the five-day course in adults was good in 3/24, fair in 13/24, poor in 8/24, while in children it was good in 14/26, fair in 9/26, poor in 3/26. The difference between adults and children is statistically significant. None of the responder patients submitted to surgical operation needed platelet infusions during surgery. Response to the "bolus" schedule (6 cases) in adults was poor in 1 case and good in the other one, and in children, fair in 3 cases and good in the other one. In responder patients treated for bleeding episodes we obtained clinical improvement with hemorrhage arrest. In adults the treatment was well-tolerated, while in children we observed 3/30 mild side effects and 1/30 important side effect.
我们对56例患有特发性血小板减少性紫癜的成人（26例）和儿童（30例）进行了56次高剂量静脉免疫球蛋白（HDIVG）给药，采用了两种不同的方案：400毫克/千克/天的五日疗程和1克/千克的“大剂量推注”。45例为手术准备而接受治疗，11例为出血发作而接受治疗。成人接受五日疗程治疗的反应为：良好3/24，中等13/24，差8/24；而儿童为：良好14/26，中等9/26，差3/26。成人和儿童之间的差异具有统计学意义。接受手术的反应者患者在手术期间均无需输注血小板。成人对“大剂量推注”方案（6例）的反应为：差1例，良好1例；儿童为：中等3例，良好1例。对于因出血发作而接受治疗的反应者患者，我们实现了临床改善，出血停止。成人对该治疗耐受性良好，而儿童中我们观察到3/30有轻微副作用，1/30有严重副作用。
