Beauchamp Jonathan, Scheibe Mandy, Hummel Thomas, Buettner Andrea
Department of Sensory Analytics, Fraunhofer Institute for Process Engineering and Packaging IVV, Giggenhauserstrasse 35, D-85354 Freising, (phone: +49-8161-491214; fax: +49-8161-491242).
Chem Biodivers. 2014 Apr;11(4):619-38. doi: 10.1002/cbdv.201300320.
Knowledge on how odorants are transported through the nasal cavity to the olfactory epithelium is limited. One facet of this is how the sniffing behavior affects the abundance of odorants transferred to the olfactory cleft and in turn influences odor perception. A novel system that couples an online mass spectrometer with an odorant pulse delivery olfactometer was employed to characterize intranasal odorant concentrations of butane-2,3-dione (or butanedione, commonly known as diacetyl) at the interior naris and the olfactory cleft. Volunteers (n=12) were asked to perform different modes of sniffing in relation to the sniff intensity that were categorized as 'normal', 'rapid' and 'forced'. The highest concentrations of butanedione at both positions in the nose were observed during normal sniffing, with the lowest concentrations correlating with periods of forced sniffs. This corresponded to the panelists' ratings that normal sniffing elicited the highest odor intensities. These feasibility assessments pave the way for more in-depth analyses with a variety of odorants of different chemical classes at various intranasal positions, to investigate the passage and uptake of odorants within the nasal cavity.
关于气味分子如何通过鼻腔传输到嗅觉上皮的知识有限。其中一个方面是嗅吸行为如何影响转移到嗅裂的气味分子数量，进而影响气味感知。一种将在线质谱仪与气味脉冲输送嗅觉计相结合的新型系统被用于表征丁二酮（或双乙酰，俗称二乙酰）在鼻内孔和嗅裂处的鼻内气味分子浓度。12名志愿者被要求根据嗅吸强度进行不同模式的嗅吸，这些模式被分类为“正常”、“快速”和“用力”。在正常嗅吸过程中，鼻子两个位置的丁二酮浓度最高，而最低浓度与用力嗅吸阶段相关。这与小组成员的评级一致，即正常嗅吸引发的气味强度最高。这些可行性评估为在鼻内不同位置对各种不同化学类别的气味分子进行更深入分析铺平了道路，以研究气味分子在鼻腔内的通过和吸收情况。
