Jordan Sue, Gabe Marie, Newson Louise, Snelgrove Sherrill, Panes Gerwyn, Picek Aldo, Russell Ian T, Dennis Michael
Department of Nursing, The College of Human and Health Sciences, Swansea University, Singleton Park, Swansea, Wales SA2 8PP, UK.
Fieldbay Ltd., Chestnut House, Tawe Business Village, Swansea Enterprise Park, Swansea SA7 9LA, UK.
ScientificWorldJournal. 2014 Feb 23;2014:843621. doi: 10.1155/2014/843621. eCollection 2014.
People with dementia are susceptible to adverse effects of medicines. However, they are not always closely monitored. We explored (1) feasibility and (2) clinical impact of nurse-led medication monitoring.
Feasibility "before-and-after" intervention study.
Three care homes in Wales.
Eleven service users diagnosed with dementia, taking at least one antipsychotic, antidepressant, or antiepileptic medicine.
West Wales Adverse Drug Reaction (ADR) Profile for Mental Health Medicines.
(1) Feasibility: recruitment, retention, and implementation. (2) Clinical impact: previously undocumented problems identified and ameliorated, as recorded in participants' records before and after introduction of the profile, and one month later.
Nurses recruited and retained 11 of 29 eligible service users. The profile took 20-25 minutes to implement, caused no harm, and supplemented usual care. Initially, the profile identified previously undocumented problems for all participants (mean 12.7 (SD 4.7)). One month later, some problems had been ameliorated (mean 4.9 (3.6)). Clinical gains included new prescriptions to manage pain (2 participants), psoriasis (1), Parkinsonian symptoms (1), rash (1), dose reduction of benzodiazepines (1), new care plans for oral hygiene, skin problems, and constipation.
Participants benefited from structured nurse-led medication monitoring. Clinical trials of our ADR Profile are feasible and necessary.
痴呆患者易受药物不良反应影响。然而,他们并未始终得到密切监测。我们探讨了(1)护士主导的药物监测的可行性和(2)临床影响。
可行性“前后”干预研究。
威尔士的三家养老院。
11名被诊断为痴呆的服务使用者,服用至少一种抗精神病药、抗抑郁药或抗癫痫药。
西威尔士精神健康药物不良反应概况。
(1)可行性:招募、留存率和实施情况。(2)临床影响:如在引入该概况前后及一个月后参与者记录中所记录的,发现并改善的先前未记录的问题。
护士从29名符合条件的服务使用者中招募并留存了11名。该概况实施耗时20 - 25分钟,未造成伤害,并补充了常规护理。最初,该概况为所有参与者识别出先前未记录的问题(平均12.7(标准差4.7))。一个月后,一些问题得到了改善(平均4.9(3.6))。临床获益包括用于管理疼痛的新处方(2名参与者)、银屑病(1名)、帕金森氏症状(1名)、皮疹(1名)、苯二氮䓬类药物剂量减少(1名),以及针对口腔卫生、皮肤问题和便秘的新护理计划。
参与者从结构化的护士主导的药物监测中获益。我们的不良反应概况的临床试验是可行且必要的。