槟榔碱贴剂的处方优化
Formulation optimization of arecoline patches.
作者信息
Wu Pao-Chu, Tsai Pi-Ju, Lin Shin-Chen, Huang Yaw-Bin
机构信息
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Department of Business Administration, I-Shou University, No. 1, Section 1, Syuecheng Road, Dashu, Kaohsiung 84001, Taiwan.
出版信息
ScientificWorldJournal. 2014 Feb 23;2014:945168. doi: 10.1155/2014/945168. eCollection 2014.
The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.
包括多项式方程在内的响应面法（RSM）已被用于设计具有适当粘附性和通量的最佳贴剂配方。贴剂配方由不同的聚合物组成，包括丙烯酸树脂RS 100（ERS）、丙烯酸树脂RL 100（ERL）和聚乙烯吡咯烷酮K30（PVP）、增塑剂（聚乙二醇400）和药物。此外，使用萜类化合物作为增强剂可以增加药物的通量。薄荷醇对槟榔碱的通量显示出最高的增强效果。
Zotero 插件