Ho Christopher Wei Guang, Mantoo Sangeeta, Lim Chin Hong, Wong Chow Yin
Department of General Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
World J Surg Oncol. 2014 Apr 8;12:88. doi: 10.1186/1477-7819-12-88.
Primary breast lymphomas (PBLs) represent less than 1% of all breast malignancies. Intravascular large B-cell lymphoma (ILBCL) is a rare, aggressive form of extranodal lymphoma. Breast involvement has only been described in the literature once previously. ILBCL is characterized by the proliferation of tumour cells within the lumen of small vessels of involved organs, resulting in their eventual occlusion. Clinical features are often vague, diagnosis is difficult and delayed, and prognosis is usually poor. We report the first ever case of synchronous ILBCL and invasive ductal carcinoma (IDC) of the breast in a patient presenting with pyrexia of unknown origin and altered mental status who underwent modified radical mastectomy and subsequent chemotherapy, and review the literature regarding intravascular large B-cell lymphoma, PBLs and synchronous carcinomas and lymphomas of the breast.
原发性乳腺淋巴瘤（PBLs）占所有乳腺恶性肿瘤的比例不到1%。血管内大B细胞淋巴瘤（ILBCL）是一种罕见的、侵袭性的结外淋巴瘤。乳腺受累此前仅在文献中被描述过一次。ILBCL的特征是肿瘤细胞在受累器官小血管腔内增殖，最终导致血管闭塞。临床特征通常不明确，诊断困难且延迟，预后通常较差。我们报告了首例同时患有乳腺ILBCL和浸润性导管癌（IDC）的病例，该患者表现为不明原因发热和精神状态改变，接受了改良根治性乳房切除术及后续化疗，并回顾了关于血管内大B细胞淋巴瘤、PBLs以及乳腺同步癌和淋巴瘤的文献。
