Cao Hailong, Qu Rui, Zhang Zhihua, Kong Xinyue, Wang Shan, Jiang Kui, Wang Bangmao
Department of Gastroenterology and Hepatology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China.
Department of Gastroenterology and Hepatology, Dongying People's Hospital, Dongying, Shandong 257091, China.
Chin Med J (Engl). 2014;127(7):1239-43.
Sporadic fundic gland polyps (FGPs) are common gastric polyps. Some studies reported that FGPs dramatically increased due to proton pump inhibitors (PPIs) use and a decreased prevalence of Helicobacter pylori (H. pylori) infection in Western countries. However, data are still controversial. This study aimed to identify the relationships between these two factors and FGPs in China.
Consecutive patients with FGPs detected were retrospectively analyzed. Data including patients' age, sex, symptoms, H. pylori infection, history of PPIs use, and the polyps were documented. Each patient was compared with two randomly selected age- and sex-matched controls with similar symptoms in the same period.
During the period from March 2011 to March 2012, a total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy and 656 patients without FGPs as controls. The mean age was (55.12±12.61) years, and 75.91% were women. The prevalence of H. pylori in patients with FGPs was significantly lower than in those without FGPs (22.30% (64/287) vs. 42.26% (224/530), P < 0.001, OR 0.392, 95% CI 0.283-0.544). Overall, a total of 54 patients with FGPs (54/328, 16.46%) and 136 patients without FGPs (136/656, 20.73%) received PPIs therapy (P = 0.110). According to the different duration of PPIs use, no significant differences of PPIs use were found between the cases and controls among all subgroups. Moreover, the PPIs use was also similar, regardless of age, sex, H. pylori infection, and the number of polyps.
Sporadic FGPs may not be induced by PPIs therapy but negatively correlate with H. pylori infection in China, which is not the same with the data in Western countries.
散发性胃底腺息肉（FGP）是常见的胃息肉。一些研究报告称，在西方国家，由于使用质子泵抑制剂（PPI）以及幽门螺杆菌（H. pylori）感染率下降，FGP显著增加。然而，数据仍存在争议。本研究旨在确定中国这两个因素与FGP之间的关系。
对连续检测出FGP的患者进行回顾性分析。记录包括患者年龄、性别、症状、H. pylori感染情况、PPI使用史以及息肉情况等数据。将每位患者与同期随机选取的两名年龄和性别匹配、症状相似的对照进行比较。
在2011年3月至2012年3月期间，在23047例行常规食管胃十二指肠镜检查的患者中，共有328例被诊断为FGP，656例无FGP的患者作为对照。平均年龄为（55.12±12.61）岁，75.91%为女性。FGP患者中H. pylori的感染率显著低于无FGP患者（22.30%（64/287）对42.26%（224/530），P<0.001，OR 0.392，95%CI 0.283 - 0.544）。总体而言，共有54例FGP患者（54/328，16.46%）和136例无FGP患者（136/656，20.73%）接受了PPI治疗（P = 0.110）。根据PPI使用的不同时长，各亚组病例与对照之间在PPI使用方面未发现显著差异。此外，无论年龄、性别、H. pylori感染情况以及息肉数量如何，PPI使用情况也相似。
在中国，散发性FGP可能不是由PPI治疗引起的，而是与H. pylori感染呈负相关，这与西方国家的数据不同。
