Halepoto Dost Muhammad, Bashir Shahid, A L-Ayadhi Laila
Department of Physiology, Faculty of Medicine, Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia.
J Coll Physicians Surg Pak. 2014 Apr;24(4):274-8.
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays a vital role in the growth, development, maintenance, and function of several neuronal systems. The purpose of this review is to document the support for the involvement of this molecule in the maintenance of normal cognitive, emotional functioning, and to outline recent developments in the content of Autism spectrum disorder (ASD). Current and future treatment development can be guided by developing understanding of this molecule's actions in the brain and the ways the expression of BDNF can be planned. Over the years, research findings suggested a critical role played by BDNF in the development of autism including increased serum concentrations of BDNF in children with autism and identification of different forms of BDNF in families of autistic individuals.
脑源性神经营养因子（BDNF）是促进生存分子的神经营养因子家族的成员之一，在多个神经元系统的生长、发育、维持和功能中发挥着至关重要的作用。本综述的目的是记录该分子参与维持正常认知、情绪功能的相关证据，并概述自闭症谱系障碍（ASD）研究内容的最新进展。通过深入了解该分子在大脑中的作用以及调控BDNF表达的方式，可以为当前和未来的治疗发展提供指导。多年来，研究结果表明BDNF在自闭症的发展中起着关键作用，包括自闭症儿童血清BDNF浓度升高以及在自闭症个体家庭中发现不同形式的BDNF。
