Division of Cardiovascular Diseases, University of California, Irvine, Calif; Department of Biomedical Engineering, University of California, Irvine, Calif.
Division of Cardiovascular Diseases, University of California, Irvine, Calif; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
J Vasc Surg. 2014 Aug;60(2):318-24. doi: 10.1016/j.jvs.2014.02.052. Epub 2014 Apr 4.
Ruptured aortic aneurysm is a condition with a high rate of mortality that requires prompt surgical intervention. It has been noted that in some conditions requiring such prompt intervention, in-hospital mortality is increased in patients admitted on the weekends compared with patients admitted on weekdays. We sought to determine if this was indeed the case for both ruptured thoracic aortic aneurysms (TAA) and abdominal aortic aneurysms (AAA) and to elucidate the possible reasons.
Using the Nationwide Inpatient Sample, a publicly available database of inpatient care, we analyzed the incidence of mortality among 7200 patients admitted on the weekends compared with weekdays for ruptured aortic aneurysm. Among these patients, 19% had a TAA and 81% had an AAA, and each group was analyzed for differences in mortality during the hospitalization. We adjusted for demographics, comorbid conditions, hospital characteristics, rates of surgical intervention, timing of surgical intervention, and use of additional therapeutic measures.
Patients admitted on the weekend for both ruptured TAA and AAA had a statistically significant increase in mortality compared with those admitted on the weekdays (TAA: odds ratio, 2.55; 95% confidence interval, 1.77-3.68; P = .03; AAA: odds ratio, 1.32; 95% confidence interval, 1.13-1.55; P = .0004). Among those with TAA, a surgical intervention was performed on day of admission in 62.1% of weekday admissions vs 34.9% of weekend admissions (P < .0001). This difference was much smaller among those with an aortic aneurysm; 79.6% had a surgical intervention on day of admission on a weekday vs 77.2% on the weekend (P < .0001).
Weekend admission for ruptured aortic aneurysm is associated with an increased mortality compared with admission on a weekday, and this is likely due to several factors including a delay in prompt surgical intervention.
主动脉夹层破裂是一种死亡率很高的疾病,需要及时进行手术干预。据报道,在某些需要及时干预的情况下,与周内工作日相比,周末入院的患者的院内死亡率更高。我们试图确定这种情况是否确实同时适用于破裂性胸主动脉瘤(TAA)和腹主动脉瘤(AAA),并阐明可能的原因。
我们使用全国住院患者样本(一种公共可用的住院患者护理数据库),分析了 7200 例周末和周内因主动脉夹层破裂入院的患者的死亡率。这些患者中,19%患有 TAA,81%患有 AAA,我们分析了每组患者在住院期间死亡率的差异。我们对人口统计学、合并症、医院特征、手术干预率、手术干预时间以及额外治疗措施的使用进行了调整。
与周内工作日相比,周末因破裂性 TAA 和 AAA 入院的患者死亡率有统计学意义的增加(TAA:优势比,2.55;95%置信区间,1.77-3.68;P =.03;AAA:优势比,1.32;95%置信区间,1.13-1.55;P =.0004)。在 TAA 患者中,周内工作日入院的患者中有 62.1%在入院当天进行了手术干预,而周末入院的患者中这一比例为 34.9%(P <.0001)。在患有腹主动脉瘤的患者中,这种差异要小得多;周内工作日入院的患者中有 79.6%在入院当天进行了手术干预,而周末入院的患者中这一比例为 77.2%(P <.0001)。
与周内工作日相比,周末因主动脉夹层破裂入院与死亡率增加相关,这可能是由于多种因素导致,包括及时手术干预的延迟。