Carcillo Joseph A
Department of Pediatrics and Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Early Hum Dev. 2014 Mar;90 Suppl 1:S45-7. doi: 10.1016/S0378-3782(14)70015-5.
This is a synopsis of the term newborn and infant portion of the 2007 document (Brierley et al., Crit Care Med 2009;37(2):666-88) which examined and graded new studies performed to test the utility and efficacy of the 2002 recommendations. This 2007 document examined and graded relevant new treatment and outcome studies to determine to what degree, if any, the 2002 guidelines should be modified. More than 30 clinical investigators and clinicians affiliated with the Society of Critical Care Medicine who had special interest in hemodynamic support of pediatric patients with sepsis volunteered to be members of the "update" task force. Subcommittees were formed to review and grade the literature using the evidence-based scoring system of the American College of Critical Care Medicine. The literature was accrued in part by searching PUBMED/MEDLINE using the following keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, and ECMO. The search was narrowed to identify studies specifically relevant to term newborns, infants, and children. "Best Practice Outcomes" were identified and described clinical practice in these centers was used as a model. The new taskforce is presently working on updating new guidelines evaluating the literature of the past 6 years.
这是2007年文档中有关足月儿及婴儿部分的内容概要（Brierley等人，《危重病医学》2009年；37(2):666 - 88），该文档对为检验2002年建议的实用性和有效性而开展的新研究进行了审查和分级。这份2007年的文档审查并分级了相关的新治疗及转归研究，以确定2002年指南应在何种程度上（若有必要）进行修改。30多位对脓毒症小儿患者血流动力学支持有特殊兴趣、隶属于危重病医学会的临床研究人员和临床医生自愿成为“更新”特别工作组的成员。成立了多个小组委员会，使用美国危重病医学会基于证据的评分系统对文献进行审查和分级。文献收集工作部分通过使用以下关键词在PUBMED/MEDLINE中检索完成：脓毒症、败血症、脓毒性休克、内毒素血症、持续性肺动脉高压、一氧化氮和体外膜肺氧合。检索范围缩小至识别与足月儿、婴儿及儿童特别相关的研究。确定了“最佳实践转归”，并将这些中心的临床实践用作范例。新的特别工作组目前正在致力于更新评估过去6年文献的新指南。
