aDepartment of Urology and Transplantation bDepartment of Genitourinary and Vascular Imaging, Edouard Herriot Hospital, Hospices Civils de Lyon cTherapeutic Applications of Ultrasound Research Laboratory, Unit 1032(LabTau), INSERM, Lyon University, Lyon, France.
Curr Opin Urol. 2014 May;24(3):225-30. doi: 10.1097/MOU.0000000000000053.
High-intensity focused ultrasound (HIFU) has been widely used for whole gland ablation with large series. HIFU induces immediate and irreversible coagulative necrosis with sharply delineated boundaries making HIFU an attractive treatment option for focal therapy of localized prostate. The treatment can be accurately targeted to a portion of the prostate gland. Unlike radiation, there is no lifetime dose limit, allowing HIFU to be repeated if necessary. Additional radical therapy can be performed involving radical surgery, external beam radiation therapy and cryotherapy. Moreover, HIFU is a minimally invasive therapy that can be performed under spinal anesthesia on an outpatient basis.
Focal therapy is a new treatment modality for localized prostate cancer. Different energy can be employed to achieve focal therapy including HIFU. With a transrectal treatment, HIFU is one of the less invasive focal treatments. A systematic review of the literature has been performed to highlight the results of focal HIFU.
The first published results of focal HIFU are promising. The patient's quality of life and potency are well preserved with good early oncological results.
高强度聚焦超声（HIFU）已被广泛用于全腺体消融，并有大量的相关研究。HIFU 可立即产生不可逆转的凝固性坏死，边界清晰，因此成为局限性前列腺疾病局灶治疗的一种有吸引力的治疗选择。该治疗方法可以精确地靶向前列腺的一部分。与放射治疗不同，HIFU 没有终身剂量限制，如果需要，可以重复治疗。还可以进行额外的根治性治疗，包括根治性手术、外照射放射治疗和冷冻治疗。此外，HIFU 是一种微创治疗方法，可以在门诊进行脊髓麻醉下进行。
局灶治疗是局限性前列腺癌的一种新的治疗方式。可以采用不同的能量来实现局灶治疗，包括 HIFU。经直肠治疗，HIFU 是一种侵袭性较小的局灶治疗方法之一。对文献进行了系统综述，以突出聚焦 HIFU 的结果。
聚焦 HIFU 的首批发表结果令人鼓舞。患者的生活质量和性功能得到很好的保留，早期肿瘤学结果良好。
